protein

Amyloid Beta

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Amyloid Beta: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

713Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	Amyloid Beta
Associated Diseases	ALZHEIMER'S DISEASE, Als, Alzheimer, Alzheimer Disease, Cancer
Known Drugs/Compounds	Anti-Amyloid Beta Therapies, Hdac Inhibitors, D-520, Disease-modifying therapy
Interactions	TGM2, AMYLOID, HMGB1, GHRL, IGF-1, HDAC
KG Connections	393 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Amyloid_Beta["Amyloid Beta"] -->|"contributes to"| Alzheimer_s_Disease["Alzheimer's Disease"]
    style Alzheimer_s_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Amyloid_Beta["Amyloid Beta"] -->|"binds"| Microglia["Microglia"]
    style Microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Amyloid_Beta["Amyloid Beta"] -->|"activates"| Microglial_Activation["Microglial Activation"]
    style Microglial_Activation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Amyloid_Beta["Amyloid Beta"] -->|"associated"| Alzheimer_Disease["Alzheimer Disease"]
    style Alzheimer_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Amyloid_Beta["Amyloid Beta"] -->|"causes"| Retinal_Degeneration["Retinal Degeneration"]
    style Retinal_Degeneration fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Amyloid_Beta["Amyloid Beta"] -->|"regulates"| LC3B["LC3B"]
    style LC3B fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    Amyloid_Beta["Amyloid Beta"] -->|"regulates"| SQSTM1["SQSTM1"]
    style SQSTM1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    Microglia_1["Microglia"] -->|"associated"| Amyloid_Beta["Amyloid Beta"]
    style Microglia_1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Lecanemab["Lecanemab"] -->|"targets"| Amyloid_Beta["Amyloid Beta"]
    style Lecanemab fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Donanemab["Donanemab"] -->|"targets"| Amyloid_Beta["Amyloid Beta"]
    style Donanemab fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Anti_Amyloid_Beta_Therapies["Anti-Amyloid Beta Therapies"] -->|"targets"| Amyloid_Beta["Amyloid Beta"]
    style Anti_Amyloid_Beta_Therapies fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Alzheimer_S_Disease["Alzheimer'S Disease"] -->|"associated"| Amyloid_Beta["Amyloid Beta"]
    style Alzheimer_S_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    style Amyloid_Beta fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (277)

Target	Relation	Type	Str
Alzheimer's Disease	contributes_to	disease	0.95
Alzheimer'S Disease	causes	disease	0.95
Alzheimer'S Disease	contributes_to	disease	0.95
Retinal Degeneration	causes	phenotype	0.95
Neuritic Plaques	involved_in	phenotype	0.95
Parkinson'S Disease With Dementia	involved_in	disease	0.95
Neuritic Plaques	promotes	phenotype	0.95
ALZHEIMER'S DISEASE	associated_with	disease	0.92
LC3B	upregulates	gene	0.90
SQSTM1	upregulates	gene	0.90
Alzheimer'S Disease	biomarker_for	disease	0.90
Optic Nerve Sheath	transports	cell_type	0.90
Senile Plaques	contributes_to	phenotype	0.90
Alzheimer Disease	causes	disease	0.90
Amyloid Plaques	mediates	phenotype	0.90
Striatum	associated_with	brain_region	0.90
Microglia	interacts_with	cell_type	0.90
Cognitive Decline	contributes_to	phenotype	0.90
Insulin Resistance	promotes	process	0.85
Visual Impairment	causes	phenotype	0.85
Neuron	causes	cell_type	0.85
Oligodendrocyte Progenitor Cell Senescence	causes	process	0.85
Apoptosis	causes	process	0.85
Lysosomal Dysfunction	associated_with	process	0.85
Lipid Dyshomeostasis	causes	phenotype	0.85
Tau	associated_with	protein	0.80
ALZHEIMER'S DISEASE	biomarker_for	disease	0.80
Alzheimer'S Retinopathy	biomarker_for	disease	0.80
Immuno-Metabolic Perturbations	mediates	mechanism	0.80
Insulin Resistance	causes	process	0.75
TAU	upregulates	protein	0.75
Cellular And Molecular Processes	interacts_with	process	0.70
Alzheimer	therapeutic_target	disease	0.60
Als	therapeutic_target	disease	0.60
Dementia	therapeutic_target	disease	0.60
Parkinson	therapeutic_target	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Ischemia	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
Cancer	associated_with	disease	0.60
Prion Disease	stabilizes	disease	0.60
Alzheimer	associated_with	disease	0.60
Parkinson	stabilizes	disease	0.60
Huntington	stabilizes	disease	0.60
Alzheimer	regulates	disease	0.60
Aging	regulates	disease	0.60
Neurodegeneration	regulates	disease	0.60
Stroke	regulates	disease	0.60
Parkinson	regulates	disease	0.60
Aging	biomarker_for	disease	0.60

Incoming (436)

Source	Relation	Type	Str
Anti-Amyloid Beta Therapies	targets	drug	0.95
Alzheimer'S Disease	associated_with	disease	0.95
APP	mediates	protein	0.95
Autophagy	targets	process	0.90
Intramural Periarterial Drainage	involved_in	process	0.90
Hdac Inhibitors	associated_with	drug	0.90
Autophagy	degrades	process	0.90
Lyso-Chr2	promotes	protein	0.90
AQP4	associated_with	gene	0.90
Cerebrospinal Fluid	transports	cell_type	0.90
Ocular Glymphatic System	transports	process	0.90
D-520	targets	drug	0.90
Disease-Associated Microglia	interacts_with	cell_type	0.90
Amyloid-Related Imaging Abnormalities	associated_with	biomarker	0.90
LL37	binds	protein	0.90
Lysosomes	involved_in	cell_type	0.85
Hdac Inhibitors	inhibits	drug	0.85
Secretases	regulates	enzyme	0.85
ACE1	associated_with	enzyme	0.85
Disease-modifying therapy	targets	drug	0.85
Microglia	involved_in	cell_type	0.85
Blood-Brain Barrier	transports	brain_region	0.85
Microglia	interacts_with	cell_type	0.80
Astrocytes	interacts_with	cell_type	0.80
APOE	transports	protein	0.80
Microglia	transports	cell_type	0.80
TAU	therapeutic_target	gene	0.60
AMYLOID	associated_with	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
AMYLOID	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
TFEB	associated_with	gene	0.60
RAB9A	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
CYP19A1	associated_with	gene	0.60
WDR45	associated_with	gene	0.60
RAS	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
PRESENILIN	associated_with	gene	0.60
VDAC2	associated_with	gene	0.60
HUNTINGTON	stabilizes	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PARKINSON	stabilizes	gene	0.60
ALZHEIMER	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Amyloid Beta

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Corticobasal Syndrome (CBS)

Novel Therapy Index

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

CBS/PSP Supplements Guide

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

nhp-validation-animal-model

Neuroresilience Mechanisms and Evidence

NPM1 Gene

PI-2620 Tau PET in PSP

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

neuroinflammation

GRIA3 Gene

Alzheimer's Disease

Microglial Cells — Cell Type Hierarchy